SINCE The second world war, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in several people. This is not just about brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall consider the various factors that decide picking a a certain drug.
Safety: The next sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug even if it’s certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the possible side-effect of addiction.
* Long-term safety: directory could possibly be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals reply to make a different chemical, which has an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This makes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same effect on exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the medicine is more intense.
Tolerability: A drug could possibly be effective but not tolerable by all patients. Example: Allergies to certain drugs in a few people. Short-term and long-term tolerability have to be looked at. Efficacy: A drug isn’t equally efficient at all patients. As an example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are lots of that don’t, who therefore have to be prescribed some other anti-depressant. The interest rate of beginning of therapeutic action is a crucial step to be regarded too.
Cost: Cost does not always mean the cost of acquisition of a specific medicine alone. It must also cover the cost of management of a complication that could arise while using some other drug. Example: Inside a person who insists on taking alcohol nevertheless needs to be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (for example tricyclics) can cause a new overuse injury in such patients, which will require a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram instead of a cheaper tricyclic in these patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you find an option between an injection and oral administration, rogues is preferred if your efficacy of both the modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to decide simple treatment.
Check out about directory have a look at our new web page: read more