SINCE World war 2, medical science has progressed with a stage where competitive medications are around to treat the identical ailment in various people. This is simply not almost brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall look at the various factors that decide picking a a certain drug.
Safety: The following sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even though it’s certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: medication directory might be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals react to create a different chemical, which has an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of one another, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This makes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually produce the same influence on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicine is more serious.
Tolerability: A drug might be effective but not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A drug just isn’t equally effective in all patients. For example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are several that don’t, who therefore should be prescribed a different anti-depressant. The pace of oncoming of therapeutic action is a crucial the answer to be regarded too.
Cost: Cost does not necessarily mean the price tag on acquisition of some medicine alone. It should also cover the price tag on treatment of a complication that will arise from using a different drug. Example: Within a person who insists on taking alcohol but should be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (such as tricyclics) may cause a fresh condition in such patients, which would demand a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in these patients.
Simple treatment: The best mode of administration is preferred. When there is a choice between an injection and oral administration, rogues is preferred when the efficacy of the two modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to make a decision simple treatment.
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