SINCE Wwii, medical science has progressed to some stage where competitive medications are for sale to treat exactly the same ailment in numerous people. It’s not just about brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall go through the various factors that decide your selection of a certain drug.
Safety: These sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug regardless of whether it has certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: medication may be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals reply to create a different chemical, that have an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other person, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon due to the metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same influence on exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the drugs are more intense.
Tolerability: A medicine may be effective and not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability need to be considered. Efficacy: A medicine is just not equally good at all patients. By way of example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are many that don’t, who therefore need to be prescribed some other anti-depressant. The interest rate of start of therapeutic action is a vital the answer to be regarded as too.
Cost: Cost does not always mean the expense of acquisition of a certain medicine alone. It should also cover the expense of treatment of a complication that could arise while using some other drug. Example: In a person who insists on taking alcohol but must be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (for example tricyclics) can cause a brand new symptom in such patients, which would need a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simple treatment: The easiest mode of administration is preferred. If you have a choice between a shot and oral administration, the second is preferred if your efficacy of the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to choose simplicity of treatment.
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