SINCE Wwii, medical science has progressed to some stage where competitive medications are available to treat the same ailment in various people. It’s not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall glance at the various factors that decide picking a a certain drug.
Safety: These sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug even though it’s certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: directory could possibly be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals answer produce a different chemical, which has an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other person, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This will cause more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same impact on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both medicines are more serious.
Tolerability: A medication could possibly be effective although not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability should be considered. Efficacy: A medication just isn’t equally great at all patients. By way of example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are several who don’t, who therefore should be prescribed some other anti-depressant. The pace of start of therapeutic action is a key to be regarded too.
Cost: Cost does not always mean the expense of buying a particular medicine alone. It should also cover the expense of treating a complication that will arise while using some other drug. Example: Inside a one who insists on taking alcohol nevertheless must be treated for depression is usually administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (for example tricyclics) can cause a brand new problem in such patients, which will have to have a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simple treatment: Most effective mode of administration is preferred. If there is a selection between a shot and oral administration, the second is preferred in the event the efficacy of both modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to determine simple treatment.
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